Prof Gunanti Develops Innovative Therapy for Bone, Tumor and Heart

Professor of the School of Veterinary Medicine and Biomedical Science (SKHB) IPB University, Prof. Gunanti succeeded in developing innovative therapies to treat tumors, healing bones to the heart. Before being applied to humans, Prof Gunanti had tested this therapy on animal models.
In her presentation during the Professor's Pre-Scientific Oration Press Conference, (11/8), Prof Gunanti said that more than 2400 years ago, it was recognized that by studying animals, humans can learn a lot about themselves. The use of animal models has now grown rapidly in almost all fields of biomedical research, not only limited to basic biology, but also in the fields of immunology, infectious diseases, oncology, and behavior.
“Our research using animal models started in 2002. We used animal models of mice, rabbits, dogs, sheep and pigs with various medical interventions. Starting from reproductive engineering, tumor induction, kidney transplantation, making bone defects, therapy for sepsis, autotransfusion experiments, to the latest, heart therapy with stem cells," she explained.
For the treatment of tumor cases, Prof. Gunanti and her team succeeded in developing herbs from the Nusa Indah blustru plant, temu putih and taro leaves. Tests were carried out with tumor induction and systemic herbal therapy to rabbits and mice. Tumors were successfully induced in rabbit mammary and mouse skin.
“The results of the use of herbal therapy show that the herbs applied have an effect in the form of decreasing tumor size, mitosis and angiogenesis. The results of this research are a happy result for us as well as a new hope for the development of herbal therapies in tumor cases," she said.
Meanwhile, she continued, for bone healing therapy, in 2014 Prof. Gunanti tried to do research on delayed bone healing which was treated with insulin-like growth factor and estradiol. Research results show that these two preparations accelerate the healing of bone fractures.
According to her, this result is a new hope for the orthopedic world, so that one more alternative therapy for bone healing is added. "From 2013 to 2018, we conducted research on the development of a three-dimensional biphasic calcium phosphate scaffold biomaterial implant for bone defects with egg shells and alginate from seaweed, which are abundant in Indonesia," she explained.
She further said, “In our bone healing research, we used animal models of New Zealand White rabbits and sheep. The results of this research show that the biphasic calcium phosphate three-dimensional scaffold implant with alginate is biocompatible and capable of inducing bone formation or osteoinduction."
For the treatment of heart disease, Prof Gunanti uses a pig animal model. According to her, in Indonesia, the case fatality rate of myocardial infarction is the highest compared to other heart diseases. Prof. Gunanti is looking for other methods that can be used to restore heart function due to myocardial infarction and prevent heart failure.
“Stem cells are cells that have the ability to self-renew and differentiate into several types of cells with specific cellular functions. One type of stem cell that can be used is Amniotic Epithelial Cells or AEC. In terms of cost, amnion is also very affordable because it can be obtained from childbirth, which is usually considered medical waste,” she explained.
“In 2021, the AEC collection was successfully carried out with viability reaching 98 percent without contamination. The animal model used in this research is a pig. The reason for using pigs in this cardiac therapy research is the similarity of heart size and weight, heart anatomy, blood vessels, ventricular activity, and heart electrophysiology, which are similar to humans," she explained.
She added that until now the therapeutic innovation that will be applied to humans is stem cell therapy to treat infarction (heart muscle disorders). Related to this, Prof Gunanti has collaborated with doctors at the University of Riau and the University of Indonesia.
"It will be applied to humans in two years. It has been tested on rats, rabbits and pigs. The pig's heart is very similar to the human heart. I hope that stem cells, which are the key to the success of heart therapy, can be carried out well," she said. (Zul) IAAS/SAT


Published Date : 11-Aug-2022

Resource Person : Prof Gunanti

Keyword : Stem Cell, IPB University, Professor, Pre Oration