Metabolomic Contribution in Predicting Active Plant Compounds for the Herbal Medicine Industry

Tropical Biopharmaca Research Center (Trop BRC) and Metabolomic Research Cluster, Institute for Research and Community Service (LPPM) IPB University held a public lecture on metabolomics, (30/6). The event invited Assoc Prof. Alfi Khatib from the Department of Pharmaceutical Chemistry, Pharmacognosy Research Group, International Islamic University Malaysia who is also an alumni of IPB University's Food and Nutrition Technology.

Prof. Alfi explained the metabolomic contribution in herbal medicinal science and application examples. Metabolomic itself has a comprehensive analysis of all metabolomes through a holistic approach. A classic example of metabolomic analysis is to use the bioassay guided isolation method. Molecular fractions are analyzed and the final result will be pure compounds.

In fact, this metabolomic still cannot stand alone. Genomic and proteomic contributions are still needed to determine the organism's biological functions and systems. The metabolomic application can be in the form of analysis of bioactive compounds in an herbal plant extract, quality control of herbal medicinal products and analysis of the bioactivity and toxicity of an herbal product.  The application is applied to samples which will be analyzed using chemical profilling or bioactivity tests in vitro and in vivo.

He has carried out case studies on the Clinacanthus nutans plant, better known as the elephant trunk or dandang gendis. Leaf extract from the plant is known as a traditional medicine for snakebite, itching or for people with diabetes. Metobalomic analysis of the leaf extract will give the results in the form of predictive compounds which can then be utilized in the drug world based on their molecular interactions.

This metabolomic study opens the opportunity for faster identification of bio novel and chemical markers. Metabolomic analysis can also be used as a validated calibration model to predict the bioactivity of a sample.  But it still cannot be applied to samples from different regions or different varieties. "So actually this is for in-house control, it cannot be used in one country," he said. (IAAS/ISL)



Published Date : 30-Jun-2020

Resource Person : Prof Alfi Khatib

Keyword : LPPM IPB University, Alfi Khatib, metabolomik, IPB alumni